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NFL Leaders |
Rushing Touchdowns
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1t | A. Ekeler | LAC | 17 | 204 | 915 | 53.8 | 4.49 | 13 |
| 1t | D. Henry | Ten | 16 | 349 | 1538 | 96.1 | 4.41 | 13 |
| 3t | N. Chubb | Cle | 17 | 302 | 1525 | 89.7 | 5.05 | 12 |
| 3t | J. Jacobs | LV | 17 | 340 | 1653 | 97.2 | 4.86 | 12 |
| 5t | J. Allen | Buf | 16 | 124 | 762 | 47.6 | 6.15 | 7 |
| 5t | N. Harris | Pit | 17 | 272 | 1034 | 60.8 | 3.80 | 7 |
| 5t | J. Mixon | Cin | 14 | 210 | 814 | 58.1 | 3.88 | 7 |
| 8t | J. Burrow | Cin | 16 | 75 | 257 | 16.1 | 3.43 | 5 |
| 8t | T. Etienne Jr. | Jax | 17 | 220 | 1125 | 66.2 | 5.11 | 5 |
| 8t | T. Lawrence | Jax | 17 | 62 | 291 | 17.1 | 4.69 | 5 |
| 8t | L. Murray | Den | 13 | 171 | 760 | 58.5 | 4.44 | 6 |
| 8t | I. Pacheco | KC | 17 | 170 | 830 | 48.8 | 4.88 | 5 |
| 8t | D. Singletary | Buf | 16 | 177 | 819 | 51.2 | 4.63 | 5 |
| 8t | R. Stevenson | NE | 17 | 210 | 1040 | 61.2 | 4.95 | 5 |
| 15t | K. Drake | Bal | 12 | 109 | 482 | 40.2 | 4.42 | 4 |
| 15t | B. Hall | NYJ | 7 | 80 | 463 | 66.1 | 5.79 | 4 |
| 15t | P. Mahomes | KC | 17 | 61 | 358 | 21.1 | 5.87 | 4 |
| 15t | D. Pierce | Hou | 13 | 220 | 939 | 72.2 | 4.27 | 4 |
| 15t | J. Taylor | Ind | 11 | 192 | 861 | 78.3 | 4.48 | 4 |
| 20t | M. Carter | NYJ | 16 | 114 | 402 | 25.1 | 3.53 | 3 |
| 20t | G. Edwards | Bal | 9 | 87 | 433 | 48.1 | 4.98 | 3 |
| 20t | C. Edwards-Helaire | KC | 10 | 71 | 302 | 30.2 | 4.25 | 3 |
| 20t | D. Harris | NE | 11 | 106 | 462 | 42.0 | 4.36 | 3 |
| 20t | K. Hunt | Cle | 17 | 123 | 468 | 27.5 | 3.80 | 3 |
| 20t | L. Jackson | Bal | 12 | 112 | 764 | 63.7 | 6.82 | 3 |
| 20t | R. Mostert | Mia | 16 | 181 | 891 | 55.7 | 4.92 | 3 |
| 20t | K. Pickett | Pit | 13 | 55 | 237 | 18.2 | 4.31 | 3 |
| 20t | J. Robinson | NYJ | 11 | 110 | 425 | 38.6 | 3.86 | 3 |
| 20t | R. Wilson | Den | 15 | 55 | 277 | 18.5 | 5.04 | 3 |
| 20t | J. Wilson Jr. | Mia | 16 | 176 | 860 | 53.8 | 4.89 | 5 |
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