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NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | M. Garrett | Cle | 16 | 60 | 16.0 | 91.0 | 0 | 2 | 4 |
| 2t | C. Jones | KC | 17 | 44 | 15.5 | 105.5 | 0 | 2 | 4 |
| 2t | M. Judon | NE | 17 | 60 | 15.5 | 102.5 | 0 | 2 | 3 |
| 4 | A. Highsmith | Pit | 17 | 63 | 14.5 | 118.0 | 0 | 5 | 1 |
| 5 | M. Crosby | LV | 17 | 88 | 12.5 | 102.0 | 0 | 3 | 4 |
| 6 | Q. Williams | NYJ | 16 | 55 | 12.0 | 98.5 | 0 | 2 | 4 |
| 7 | J. Uche | NE | 15 | 27 | 11.5 | 49.5 | 0 | 2 | 0 |
| 8 | C. Heyward | Pit | 17 | 74 | 10.5 | 72.5 | 0 | 1 | 4 |
| 9t | J. Houston | Bal | 14 | 21 | 9.5 | 63.0 | 1 | 1 | 1 |
| 9t | Y. Ngakoue | Ind | 15 | 29 | 9.5 | 62.5 | 0 | 1 | 0 |
| 11 | J. Hughes | Hou | 17 | 35 | 9.0 | 61.0 | 1 | 2 | 1 |
| 12t | D. Autry | Ten | 12 | 27 | 8.0 | 56.0 | 0 | 2 | 4 |
| 12t | D. Buckner | Ind | 17 | 74 | 8.0 | 48.5 | 0 | 2 | 3 |
| 12t | B. Chubb | Mia | 16 | 39 | 8.0 | 64.5 | 0 | 3 | 1 |
| 12t | T. Hendrickson | Cin | 15 | 32 | 8.0 | 47.5 | 0 | 3 | 3 |
| 12t | K. Mack | LAC | 17 | 50 | 8.0 | 58.0 | 0 | 2 | 2 |
| 12t | V. Miller | Buf | 11 | 21 | 8.0 | 54.0 | 0 | 1 | 2 |
| 12t | G. Rousseau | Buf | 13 | 37 | 8.0 | 60.5 | 0 | 1 | 4 |
| 19t | J. Simmons | Ten | 15 | 53 | 7.5 | 65.0 | 0 | 1 | 7 |
| 19t | D. Wise Jr. | NE | 17 | 59 | 7.5 | 46.5 | 0 | 2 | 3 |
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