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NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | N. Bosa | SF | 16 | 51 | 18.5 | 137.5 | 0 | 2 | 1 |
| 2 | H. Reddick | Phi | 17 | 49 | 16.0 | 132.5 | 0 | 5 | 3 |
| 3 | M. Parsons | Dal | 17 | 65 | 13.5 | 88.5 | 0 | 3 | 3 |
| 4t | B. Burns | Car | 16 | 63 | 12.5 | 83.0 | 0 | 1 | 3 |
| 4t | J. Watt | Ari | 16 | 39 | 12.5 | 94.0 | 0 | 1 | 7 |
| 6 | D. Payne | Was | 17 | 64 | 11.5 | 81.5 | 0 | 0 | 5 |
| 7t | B. Graham | Phi | 17 | 35 | 11.0 | 64.0 | 0 | 2 | 1 |
| 7t | J. Hargrave | Phi | 17 | 60 | 11.0 | 75.0 | 0 | 1 | 2 |
| 7t | J. Sweat | Phi | 16 | 48 | 11.0 | 84.0 | 1 | 1 | 1 |
| 10 | D. Hunter | Min | 17 | 65 | 10.5 | 63.0 | 0 | 1 | 3 |
| 11 | Z. Smith | Min | 16 | 44 | 10.0 | 70.5 | 0 | 2 | 5 |
| 12t | A. Hutchinson | Det | 17 | 52 | 9.5 | 59.5 | 3 | 0 | 3 |
| 12t | U. Nwosu | Sea | 17 | 67 | 9.5 | 62.5 | 0 | 3 | 4 |
| 12t | D. Taylor | Sea | 16 | 26 | 9.5 | 73.5 | 0 | 4 | 1 |
| 15 | L. Floyd | LAR | 17 | 59 | 9.0 | 64.0 | 0 | 0 | 0 |
| 16t | D. Armstrong | Dal | 17 | 33 | 8.5 | 55.5 | 0 | 1 | 0 |
| 16t | C. Jordan | NO | 16 | 66 | 8.5 | 67.5 | 0 | 2 | 2 |
| 16t | P. Smith | GB | 17 | 59 | 8.5 | 64.0 | 0 | 1 | 1 |
| 19t | J. Houston | Det | 7 | 10 | 8.0 | 58.0 | 0 | 1 | 0 |
| 19t | M. Sweat | Was | 17 | 46 | 8.0 | 59.0 | 0 | 0 | 2 |
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