NFL Football
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Final 1 2 3 4 Tot
San Francisco 7 10 7 13 37
Carolina 0 3 9 3 15
1:05 PM PT2:05 PM MT3:05 PM CT4:05 PM ET20:05 GMT4:05 1:05 PM MST3:05 PM EST2:05 PM CT0:05 UAE (+1)16:05 ET19:05 , October 9, 2022
Bank of America Stadium, Charlotte, North Carolina  Weather: 68°, Clear  Attendance: 72,321

49ers-Panthers Preview

According to STATS
According to STATS

San Francisco 49ers at Carolina Panthers

  1. Prior to the most recent win in October 2019, San Francisco had lost all six games to Carolina since 2004. In that time, it's tied for the 49ers' worst record against an NFC team (1-6, .143, vs. Dallas).
  2. San Francisco leads the league in opposing three and out percentage, ending an opponent's drive after just four plays 40.9% of the time this season. The 49ers are also the only team this season to have two separate streaks of three drives going three and out in the same game (vs. Denver on September 25).
  3. Deebo Samuel ran for 106 yards after catching six receptions in the 49ers' victory over the Rams on Monday. Only two players in the past five seasons have at least 100 yards after the catch with fewer receptions in a game, Austin Ekeler (4 in 2019 vs. Jacksonville) and Jonathan Taylor (3 in 2021 vs. Baltimore).
  4. The Carolina Panthers have thrown for just 664 net yards after four games this season. Through four games, only two Panther seasons all-time have seen fewer, with 620 in 2010 and 499 in 2003.
  5. Christian McCaffrey is one touchdown away from 50 in his career, which would tie the fifth-most touchdowns in Carolina Panther history (Muhsin Muhammad).
  6. San Francisco and Carolina sit first and second respectively in opponent yards per play in the red zone in the NFL this season: San Francisco allowing 1.18 and Carolina allowing 1.63. The only other team this season allowing fewer than 2.00 yards per play in the red zone is the Dallas Cowboys (1.71).
Team Comparison

San Francisco
17.8 Points 19.5
199.5 Pass Yds 186.8
135.3 Rush Yds 96.3
6 Takeaways 4
(AP Photo/Godofredo A. Vsquez)

CHARLOTTE, N.C. (AP) No NFL quarterback has struggled quite as much this season as Carolina's Baker Mayfield.

The bumpy road isn't expected to get any smoother on Sunday for the 2018 No. 1 overall draft pick.

Mayfield, who is last in the NFL in ESPN's total quarterback rating, leads the league's worst offense against its top-ranked defense when the Panthers (1-3) host the San Francisco 49ers (2-2).

Mayfield joined the Panthers in July after a trade with the Cleveland Browns. He has struggled mightily, completing a league-low 54.7% of his passes while being limited to 186.7 yards passing per game with four touchdowns and three interceptions.

"I pride myself on being a guy that elevates the guys around him and being able to lead at an extremely high level," Mayfield said. "And obviously, that has not happened yet."

Panthers offensive coordinator Ben McAdoo said he deserves blame too, adding that he needs to put his players in better position to make plays and find ways to get Christian McCaffrey and D.J. Moore the ball more often.

That's easier said than done against the 49ers.

San Francisco has been dominant defensively with Nick Bosa's NFL-best six sacks leading a fearsome pass rush and playmaking safety Talanoa Hufanga anchoring the back end. The Niners have given up only 37 points to opposing offenses - tied for the second fewest through four games since 2010 - and have allowed 3.81 yards per play, the lowest mark through four games since 2008.

Panthers coach Matt Rhule said "I think they're number one in every category."

"I think it's to be best in the league," Bosa said about the expectations of San Francisco's defense. "It's kind of our mindset every year and this year we have the personnel to do it. Not that we haven't in the past, but at all three levels are elite players."


When the Panthers were considering making a move at quarterback this past offseason, they pursued trades for Deshaun Watson, Jimmy Garoppolo and Mayfield.

Watson wound up in Cleveland and talks with the 49ers about Garoppolo never really got off the ground because of the money involved in taking him on.

Now they'll face Garoppolo on Sunday.

"Jimmy, he's won a lot of games there and got them to the NFC championship last year," Panthers defensive coordinator Phil Snow said. "He just wins games."


The 6-foot-1 Mayfield continues to struggle with batted balls at the line of scrimmage. He's had an NFL-high 11 this season, including five last week by Arizona - one of which was intercepted and led to a Cardinals touchdown.

McAdoo said the Panthers have worked extensively on the problem this week in practice

"It's a copycat league," McAdoo said. "So what you are seeing is teams are rushing and then once they feel that they are blocked or stymied (on the pass rush), they will put their hands up and jump."


Niners tight end George Kittle had a monster three-game stretch in late in the 2021 season, but in the eight games since he's been mediocre at best with just 21 catches for 220 yards.

"The more Kittle is out there and healthy, the more he practices, the more he can get back in the routine," 49ers coach Kyle Shanahan said. "I think that stuff will take care of itself. The plays that went to him, I thought he did a good job on in the game. Kittle affects the game in so many ways, the run and the pass."

Shanahan said the 49ers want to get the ball to Kittle more, but added, "it's something we're not that concerned about. We think it'll take care of itself as we get going."


The Panthers will be without safety Jeremy Chinn, who had back-to-back 100-tackle seasons to start his career but was lost in Week 4 to a hamstring injury. The Panthers will turn to Myles Hartsfield and Sean Chandler to fill Chinn's spot while he's on short-term injured reserve.

The versatile and athletic Chinn almost surely would have been matched up at times against dangerous 49ers wide receiver Deebo Samuel.


The 49ers will stay on the road following the game as they begin their now-annual 10-day stay back East. The Niners will head to West Virginia to practice there before playing at Atlanta in Week 6. San Francisco has done this kind of trip the previous three seasons, including twice in 2019. The Niners are 7-1 in those games.

"There is something when you go on the road, just the distractions are a little less there," Shanahan said. "The people aren't there, even in your own house, you're just kind of locked into a room and I think it just helps guys focus a little bit more. I don't know if it's a coincidence, but the numbers have definitely been a lot better."


AP Pro Football Writer Josh Dubow contributed to this report.


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Updated October 6, 2022

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